ISSN: 2791-7967
Are Peripheral Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Radio Related with Breast Cancer-Related Lymphedema?
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Original Article
VOLUME: 3 ISSUE: 1
P: 17-22
June 2022

Are Peripheral Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Radio Related with Breast Cancer-Related Lymphedema?

J Eur Med Sci 2022;3(1):17-22
DOI: 10.5578/jeurmeds.20220104
Pınar DORUK ANALAN 1
Emine ÇETİN 2
1. Başkent University Adana Dr. Turgut Noyan Application and Research Center, Clinic of Physical Medicine and Rehabilitation, Adana, Turkey
2. Adana City Training and Research Hospital, Clinic of Physical Medicine and Rehabilitation, Adana, Turkey
No information available.
No information available
Received Date: 5.02.2022
Accepted Date: 22.03.2022
Online Date: 24.06.2022
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ABSTRACT

Objective: To investigate peripheral neutrophil-lymphocyte ratio, which is an indicator of immunity and systemic inflammation, and platelet-lymphocyte ratio in patients with breast cancer and its affect on lymphedema.

Material and Methods: The patients were dichotomized into two groups, ones with breast cancer-related lymphedema (BCRL) and the control group cases with no identified BCRL. The BCRL group included 28 cases and the control group included 34. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values were compared between the groups. Intra and intergroup correlation analysis for NLR/PLR, visual analog scale (VAS), Quick Disabilities of the Arm, Shoulder, and Hand Questionnaire (Q-DASH), and the volumetric and diametric differences between the upper extremities were computed.

Results: Neutrophil-to-lymphocyte ratio was significantly higher in the control group (p= 0.035). Platelet-to-lymphocyte ratio values yielded similar results (p= 0.161). There was no correlation between NLR/PLR values and outcome parameters (r≤ 0.3; p> 0.05).

Conclusion: Neutrophil-to-lymphocyte ratio and PLR are not clinically significant for lymphedema, pain, disability, physical function, and BCRL.

Keywords: Breast cancer related lymphedema, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte