ISSN: 2791-7967
Association Between Serum NT-proBNP and Coronary Artery Ectasia
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Original Article
VOLUME: 2 ISSUE: 2
P: 55-60
July 2021

Association Between Serum NT-proBNP and Coronary Artery Ectasia

J Eur Med Sci 2021;2(2):55-60
DOI: 10,5578/jeurmeds.20210304
Arafat YILDIRIM 1
Özge ÖZCAN ABACIOĞLU 1
Mustafa DOĞDUŞ 2
Ferhat DİNDAŞ 2
Fethi YAVUZ 3
1. University of Health Sciences, Adana City Training and Research Hospital, Clinic of Cardiology, Adana, Turkey
2. Uşak University Faculty of Medicine, Department of Cardiology, Uşak, Turkey
3. Adıyaman University Faculty of Medicine, Department of Cardiology, Adıyaman, Turkey
No information available.
No information available
Received Date: 11.04.2021
Accepted Date: 15.05.2021
Online Date: 27.08.2021
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ABSTRACT

Objective: Coronary artery ectasia is defined as the dilation of at least one coronary artery 1.5 times or more than the adjacent normal coronary artery segment. Coronary ectasias, the most common cause of which is atherosclerosis, are mostly seen together with coronary artery disease (CAD), but can also be detected in isolation. The relationship between coronary artery ectasia (CAE) and N-terminal pro B-type natriuretic peptide (NT-pro BNP) is unknown. In this study, it was aimed to investigate whether there is a relationship between NT-proBNP level and CAE.

Material and Methods: A total of 126 patients who underwent coronary angiography between January 2018 and August 2019 and had NT-proBNP value in their blood samples were included in the study. Sixty-six patients with coronary ectasia, coronary ectasia group and 60 age-sex matched patients without coronary ectasia were included in the study as the control group. Patients with acute coronary syndrome, significant coronary artery stenosis, history of coronary intervention, mild or significant valve dysfunction, heart failure,chronic kidney or liver disease, any inflammatory or autoimmune disease, malignancy, anemia and patients without NT-proBNP value were excluded from study.

Results: Mean age of the study population was 60.2 ± 8.8 years (34.1%, n= 43, female). Mean systolic, diastolic blood pressures and smoking were significantly higher in the CAE group compared to the control subjects. Mean NT-proBNP levels were statistically significantly higher in the CAE patients than the control subjects (111.32 ± 17 ng/ml vs. 98.89 ± 8.6 ng/ml, p< 0.001). In receiver operating characteristic (ROC) analysis, a cut-off value of NT-proBNP ≥95 ng/ml had 85.3% sensitivity and 58.8% specificity for predicting CAE (area under the curve: 0.772, p< 0.001). Multivariate analysis showed that smoking (OR= 1.799; p= 0.024) and NT-ProBNP (OR= 1.094; p< 0.001) were independently associated with CAE.

Conclusion: Coronary ectasia may cause angina pectoris as a result of turbulent flow and microvascular perfusion impairment. Relative increase of NT-proBNP may be associated with CAE. In this study, it was determined that serum NT-proBNP levels were increased significantly in patients with CAE and increased serum NT-proBNP levels were inde- pendently associated with CAE.

Keywords: N-terminal pro b-type natriuretic peptide, coronary artery ectasia, myocardial ischemia