ISSN: 2791-7967
Effects Of Anticancer Treatment On C-Reactive Protein And Procalcitonin Levels In Patients With Infection
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Research Article
VOLUME: 1 ISSUE: 3
P: 71-78
November 2020

Effects Of Anticancer Treatment On C-Reactive Protein And Procalcitonin Levels In Patients With Infection

J Eur Med Sci 2020;1(3):71-78
DOI: 10.37609/cmj.1511
Kübra İrday Demir 1
Ayşe Erbay 2
Nalan Yazıcı 2
Özgür Ceylan 2
Mehmet Cenk Belibağlı 3
1. SBÜ Adana Şehir Eğitim ve Araştırma Hastanesi
2. Başkent üniversitesi Adana Turgut Noyan uygulama ve Araştırma Hastanesi
3. SBÜ Adana Şehir Eğitim ve Araştırma Hastanesi Aile Hekimliği
No information available.
No information available
Received Date: 27.11.2020
Accepted Date: 15.12.2020
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ABSTRACT

Objective

Chemotherapy and radiotherapy treatment affects all the cell functions in the body. Removing malignant cells comes with a cost of impairment of other cells and systems, including the synthesis of C-reactive protein (CRP) and Procalcitonin (PCT). This study aimed to compare the CRP and PCT responses in fever attacks of pediatric patients with cancer and non-cancer ones.

Materials and methods

We conducted a retrospective and cross-sectional study analyzing the medical files of 179 pediatric patients hospitalized at the University of Başkent Adana Dr. Turgut Noyan Application and Research Center Pediatric Ward between 01.01.2014 and 31.12.2016. Patients with cancer and received chemo and or radiotherapy treatment, with reports of fever attacks of infection origin, were selected for the study group, and patients with reports of fever attacks of infection origin and did not have a history of cancer were chosen for the control group. The study group’s inclusion criteria were; aged between one month and 18 years, received cancer therapy, having reports of fever attacks, and tested for CRP, PCT, complete blood count, and basic blood biochemistry. Statistical Package for Social Sciences (SPSS) 17.0 was used in data analysis. Critical significance was set as 0.05.

Results

The study consisted of a very heterogeneous population. Overall, there were a total of 234 fever attacks recorded. The comparison of the CRP and WBC levels of the study group showed a negative correlation (r: -0.31, p=0.001). Similarly, CRP levels increased as the neutropenia deepened (p<0.001). On the contrary, in the control group, CRP levels increased parallel to the WBC levels (r: 0.245, p=0.008). The analysis of the study group showed that an increase in PCT levels was associated with prolonged iv antibiotic treatment duration in patients with PCT levels over 0.5 mg/dL and had lymphoma or leukemia (p= 0.034).

Conclusion

In this novel study, the CRP and PCT levels in infections of pediatric patients with cancer and receiving cancer therapy and ones not diagnosed with cancer were compared. There was no superiority between CRP and PCT was found in predicting infection severity in the pediatric population.